Comparison of Plasma Lipoprotein Composition and Function in Cerebral Amyloid Angiopathy and Alzheimer’s Disease

Bonaterra-Pastra, Anna and Fernández-de-Retana, Sofia and Rivas-Urbina, Andrea and Puig, Núria and Benítez, Sònia and Pancorbo, Olalla and Rodríguez-Luna, David and Pujadas, Francesc and del Mar Freijo, Maria and Tur, Silvia and Martínez-Zabaleta, Maite and Cardona Portela, Pere and Vera, Rocío and Lebrato-Hernández, Lucia and Arenillas, Juan F. and Pérez-Sánchez, Soledad and Montaner, Joan and Sánchez-Quesada, Jose Luis and Hernández-Guillamon, Mar (2021) Comparison of Plasma Lipoprotein Composition and Function in Cerebral Amyloid Angiopathy and Alzheimer’s Disease. Biomedicines, 9 (1). p. 72. ISSN 2227-9059

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Abstract

Cerebral amyloid angiopathy (CAA) refers to beta-amyloid (Aβ) deposition in brain vessels and is clinically the main cause of lobar intracerebral hemorrhage (ICH). Aβ can also accumulate in brain parenchyma forming neuritic plaques in Alzheimer’s disease (AD). Our study aimed to determine whether the peripheral lipid profile and lipoprotein composition are associated with cerebral beta-amyloidosis pathology and may reflect biological differences in AD and CAA. For this purpose, lipid and apolipoproteins levels were analyzed in plasma from 51 ICH-CAA patients (collected during the chronic phase of the disease), 60 AD patients, and 60 control subjects. Lipoproteins (VLDL, LDL, and HDL) were isolated and their composition and pro/antioxidant ability were determined. We observed that alterations in the lipid profile and lipoprotein composition were remarkable in the ICH-CAA group compared to control subjects, whereas the AD group presented no specific alterations compared with controls. ICH-CAA patients presented an atheroprotective profile, which consisted of lower total and LDL cholesterol levels. Plasma from chronic ICH-CAA patients also showed a redistribution of ApoC-III from HDL to VLDL and a higher ApoE/ApoC-III ratio in HDL. Whether these alterations reflect a protective response or have a causative effect on the pathology requires further investigation.

Item Type: Article
Uncontrolled Keywords: cerebral amyloid angiopathy; Alzheimer’s disease; lipoprotein composition; lipid profile; apolipoproteins
Subjects: STM Repository > Biological Science
Depositing User: Managing Editor
Date Deposited: 17 Oct 2024 04:32
Last Modified: 17 Oct 2024 04:32
URI: http://classical.goforpromo.com/id/eprint/1017

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