Splenectomy Prior to Experimental Induction of Autoimmune Hepatitis Promotes More Severe Hepatic Inflammation, Production of IL-17 and Apoptosis

Buitrago-Molina, Laura Elisa and Dywicki, Janine and Noyan, Fatih and Trippler, Martin and Pietrek, Julia and Schlue, Jerome and Manns, Michael P. and Wedemeyer, Heiner and Jaeckel, Elmar and Hardtke-Wolenski, Matthias (2021) Splenectomy Prior to Experimental Induction of Autoimmune Hepatitis Promotes More Severe Hepatic Inflammation, Production of IL-17 and Apoptosis. Biomedicines, 9 (1). p. 58. ISSN 2227-9059

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Abstract

Autoimmune hepatitis (AIH) is detected at a late stage in the course of the disease. Therefore, induction and etiology are largely unclear. It is controversial if the induction of autoimmunity occurs in the liver or in the spleen. In our experimental murine AIH model, the induction of autoimmunity did not occur in the spleen. Instead, a protective role of the spleen could be more likely. Therefore, we splenectomized mice followed by induction of experimental murine AIH. Splenectomized mice presented more severe portal inflammation. Furthermore, these mice had more IL-17, IL-23 receptor (IL-23R) and caspase 3 (casp3) and a decreased amount of erythropoietin in serum, while intrahepatic T cell compartments were unaffected. These results indicate that the spleen is not necessary for induction of AIH, and splenectomy disrupts the ability to immune regulate the intensity of hepatic inflammation, production of IL-17 and apoptosis.

Item Type: Article
Uncontrolled Keywords: autoimmune hepatitis; experimental murine hepatitis; liver; spleen; IL-17; apoptosis; inflammation; caspase-3; adenovirus; formiminotransferase cyclodeaminase
Subjects: STM Repository > Biological Science
Depositing User: Managing Editor
Date Deposited: 02 Oct 2024 08:07
Last Modified: 02 Oct 2024 08:07
URI: http://classical.goforpromo.com/id/eprint/1031

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