Genome-Wide Association Study Identifies Loci Associated with Sensitive Skin

Farage, Miranda A. and Jiang, Yunxuan and Tiesman, Jay P. and Fontanillas, Pierre and Osborne, Rosemarie (2020) Genome-Wide Association Study Identifies Loci Associated with Sensitive Skin. Cosmetics, 7 (2). p. 49. ISSN 2079-9284

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Abstract

Individuals suffering from sensitive skin often have other skin conditions and/or diseases, such as fair skin, freckles, rosacea, or atopic dermatitis. Genome-wide association studies (GWAS) have been performed for some of these conditions, but not for sensitive skin. In this study, a total of 23,426 unrelated participants of European ancestry from the 23andMe database were evaluated for self-declared sensitive skin, other skin conditions, and diseases using an online questionnaire format. Responders were separated into two groups: those who declared they had sensitive skin (n = 8971) and those who declared their skin was not sensitive (controls, n = 14,455). A GWAS of sensitive skin individuals identified three genome-wide significance loci (p-value < 5 × 10−8) and seven suggestive loci (p-value < 1 × 10−6). Of the three most significant loci, all have been associated with pigmentation and two have been associated with acne.

Item Type: Article
Subjects: STM Repository > Medical Science
Depositing User: Managing Editor
Date Deposited: 24 Jan 2023 05:44
Last Modified: 25 Jul 2024 07:29
URI: http://classical.goforpromo.com/id/eprint/2264

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