A Comparative Pharmaceutico-Analytical Study of Saindavadhi Ghrita Prepared with Murchchhit and Amurchchhit Ghrita and Evaluation of Its Antiepileptic Efficacy in Swiss Albino Mice – A Study Protocol

Background: Epilepsy accounts for a significant proportion of the world’s disease burden, affecting around 50 million people worldwide. With the increased incidence rate of epilepsy, a few treatment modalities as well as formulations are being developed in recent years, but the complete recovery from the symptoms of epilepsy is not recorded till today. However, there is a search for a formulation that shows quick and longstanding efficacy on epilepsy. Saindavadhi Ghrita is one such formulation mentioned in Yogaratnakara Apasmara Chikista.

Aim: A comparative Pharmaceutico-analytical study of Saindavadhi Ghrita prepared with Murchchhit and Amurchchhit Ghrita (MSG & ASG) and evaluation of its antiepileptic efficacy in Swiss albino mice.

Methodology: Preparation of Saindavadhi Ghrita will be carried out with Murchchhit and Amurchchhit Ghrita and an analytical study will be done. Prepared Saindavadhi Ghrita (MSG & ASG) will be evaluated for its antiepileptic action on Swiss albino mice.

Observations & Results: Analysis and Experimental study shall be documented and presented in the form of data, photographs, tables, charts, etc. as applicable. The data obtained will be analyzed by using a one-way analysis of variance (ANOVA) followed by Dunnett’s multiple comparison t-tests as a post hoc test for determining the level of significance of the observed effects.

Conclusion: MSG is expected to be to show significant antiepileptic efficacy in Swiss albino mice as compared to ASG.