Synthesis, Characterization, Thermal Analysis and Antibacterial Activity of Cu (II) and Ni(II) Complexes with Thiosemicarbazone Derived from Thiophene-2-aldehyde

Metal complexes have been synthesized by the reaction of thiophene-2- aldehyde thiosemicarbazone with Cu(OAc)2 and Ni(OAc)2. The thiosemicarbazone coordinates to metal ions through the thionic sulfur and the azomethine nitrogen. The thiosemicarbazone is obtained by the reaction of thiosemicarbazide with thiophene-2- aldehyde. The identities of these compounds have been elucidated by IR and ESI-MS spectroscopic methods and elemental analyses. Thermogravimetric analysis data indicates that the metal complexes are thermally stable. The antibacterial activity of the synthesized compounds are tested by the disc diffusion assay against Gram-positive and Gram-negative bacteria. The antibacterial screening activity revealed that complexes showed moderate activity against tested bacterial strains and slightly higher compared to the ligand, L.