Prognostic Value of NT-proBNP Concentrations in Patients Attending a Hospital Cardiac Service

Objective: Measurement of N-terminal pro-brain natriuretic peptide (NT-proBNP) in the assessment of patients with the acute coronary syndrome has appeared to be a useful prognostic marker of cardiovascular risk. The purpose of this study is to determine if the NTpro-BNP could be a biological marker in evaluating the severity of the disease in patients with the acute coronary syndrome (ACS).

Materials and Methods: This study has included 130 patients attending hospital cardiology department (Sétif Central University Hospital (Algeria)), 47 women and 83 men. All were affected by the coronary syndrome. This study was conducted for 5 months. Several tests were used, ECG, echocardiography, measurement of NT-proBNP, Homocysteine, C-reactive protein (CRP), Vitamin B9 in addition to biochemical and haematological profiles. Data were analysed using SPSS Version 21.0.

Results: The average age of coronary patients was 63.89 ± 12.68 years, with a high predominance of men (63.8%) compared to women (36.2%). There was a significant positive correlation between NT-proBNP and age, homocysteine, Hs-CRP, urea, creatinine, ASAT, ALAT, LDH, γGT, uric acid and fibrinogen. On the other side, NT-proBNP had a negative correlation with sodium, haemoglobin, creatinine clearance and LVEF. The statistical analysis a grouping patients according to NT-proBNP levels. They were separated into two groups (NT-proBNP ≤900 pg/ml, NT-proBNP>900 pg/ml). Then we correlated all parameters (biochemical, haematological, clinical signs) with the different risk factors).

Conclusion: NT-proBNP is a valuable marker for predicting the severity of coronary artery disease in patients with the acute coronary syndrome.