Effect of Daratumumab combined with Chemotherapy on Immune Function in Patients with Relapsed/Refractory Multiple Myeloma and Observation of its Clinical Efficacy

Zhang, Ye-hua and Xu, Feng and Xu, Chang-qing and Zhang, Zi-tan and Jiao, Zong-jiu (2022) Effect of Daratumumab combined with Chemotherapy on Immune Function in Patients with Relapsed/Refractory Multiple Myeloma and Observation of its Clinical Efficacy. Pakistan Journal of Medical Sciences, 39 (1). pp. 248-252. ISSN 1682-024X

[thumbnail of 6667-Article Text-41792-2-10-20221201.pdf] Text
6667-Article Text-41792-2-10-20221201.pdf - Published Version

Download (346kB)

Abstract

Objective: To evaluate the clinical efficacy and immune function of Daratumumab combined with chemotherapy in patients with relapsed/refractory multiple myeloma (RRMM).

Methods: Eighty patients with RRMM treated in Xingtai People’s Hospital from January, 2020 to December, 2021 were randomly divided into two groups. Patients in the study group were treated with Daratumumab combined with PAD regimen, while patients in the control group were provided with PAD regimen alone. Further comparison was performed on the therapeutic effects, adverse drug reactions, the levels of T lymphocyte subsets CD3+, CD4+, CD8+ and CD4+/CD8+, the positive expression rate of CD38 and the expression level of Notch-1 on the membrane of plasma cells between the two groups.

Results: The overall response rate in the study group (67.50%) was significantly better than that in the control group (45.00%). There was no significant difference in the incidence of adverse reactions between the two groups. After treatment, the reviewed levels of CD3+, CD4+ and CD4+/CD8+ were obviously higher in the study group than those in the control group, while the positive expression rate of CD38 and the expression level of Notch one on the membrane of plasma cells were both lower than those in the control group (p<0.05).

Conclusion: Daratumumab combined with a PAD regimen is a safe and effective approach that has a definite curative effect on patients with RRMM, which can improve immune function significantly and result in no significant increase in adverse reactions.

Item Type: Article
Subjects: STM Repository > Medical Science
Depositing User: Managing Editor
Date Deposited: 01 Jun 2023 06:35
Last Modified: 01 Feb 2024 04:14
URI: http://classical.goforpromo.com/id/eprint/3372

Actions (login required)

View Item
View Item