Autologous Platelet Derived Growth Factor and Fibrin Rich Plasma in Chronic Non-healing Ulcer

Background and Objectives: Chronic non-healing ulcer (CNHU) develops due to infections, trauma or underlying any medical and surgical conditions. Ulcer that have failed to response all available mode of treatment for long duration are more likely to develop gangrene and infection prone to limb amputation. This is a major public health problem. None of the conventional treatments are anticipated to stimulate active wound healing. Efficacy of topically applied autologous platelet derived growth factors and fibrin rich plasma in active repair of chronic non healing ulcer has been widely studied. Studies have proved its efficacy in early wound healing and repair by accelerating the inflammation, tissue proliferation, angiogenesis and remodeling stages. PDGF has crucial role in recruiting inflammatory cell to the wound site, stimulating these cells for release of growth factors, chemotactic factors and migration of cells. The effects vary in different cell due to different signaling transduction pathways. Numerous studies have showed the efficacy of topically applied autologous platelet derived growth factors and fibrin rich plasma in management of chronic non-healing ulcer. However, future studies are required to specify the various signaling mechanism at different stages of wound healing.