BOUSSENA, MABROUK and DJEMLI, SAMIR and TAHRAOUI, ABDELKRIM and REFES, INES and ROUAG, FAIZA and MESSIKH, SAMIA and CHOUBA, IBTISSEM and MEMOUNI, ROUYA and SELLAMI, NADJETTE LAOUABDIA (2021) THE CHRONIC EFFECT OF FORCE-FEEDING (ORAL GAVAGE) ADMINISTRATION OF ASPARTAME ON WISTAR RATS (NEPHROTOXICITY AND NEUROBEHAVIORAL TROUBLES). UTTAR PRADESH JOURNAL OF ZOOLOGY, 42 (16). pp. 107-116.
Full text not available from this repository.Abstract
Background: This study was performed to see the effect of chronic administration by gavage of aspartame on kidneys and behavior in Wistar rats.
Methods: In this study, 28 Wistar rats were used, divided into 04 groups including a control group treated with distilled water and three other groups treated with aspartame at different doses (40 mg / kg, 60 mg / kg, 1000 mg / kg body weight) for 90 days orally (gastric gavage).
Results: A highly significant increase (p <0,001) of blood urea level ASP 3 group compared to the ASP1 group (ADI Acceptable Daily Intake) , however we observe a highly significant reduction in blood creatinine level (p <0, 01) as compared to the ASP1 tolerated daily intake group. In the open field test, we notice highly significant decrease (p <0,01) in the ASP3 group treated with the 1000 mg per kg body weight dose ASP 3 compared to the group treated with the 40 mg / kg bw dose or the ADI ( Acceptable Daily Intake) ASP1.
The histopathological study of kidneys showed multiple vascular congestion with inflammatory infiltration in Group ASP3 compared to the control.
Conclusion: The chronic administarion of aspartame by gavage on Wistar rats causes kidney damage and neurobehavioral troubles.
| Item Type: | Article |
|---|---|
| Subjects: | STM Repository > Biological Science |
| Depositing User: | Managing Editor |
| Date Deposited: | 04 Dec 2023 03:53 |
| Last Modified: | 04 Dec 2023 03:53 |
| URI: | http://classical.goforpromo.com/id/eprint/4507 |
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