EFFECT OF PHENOLIC COMPOUND DRUGS ONCERTAIN METABOLITES OF LIVER IN OREOCHROMIS MOSSAMBICUS

Some common analgesic and antipyretic drugs are known to be phenolic compounds. Examples are calpol, metacin and coSavil which contain paracetamol. Liver as the detoxifying organ is known to degrade any phenolic drugs that are orally administered. Such degradative intermediates, sometimes even have carcinogenic effect. In the present study, two paracetamol drugs, calpol and flexam (the later containing an additional phenolic derivative) were orally fed to Oreochromis mossambicus on long term basis. Free amino acids, proteins, lipids in the liver have been estimated. The accumulation of phenolic compounds has not been studied as such analysis demands finer sensitive techniques. Only the possible side effects of the drugs are studied. All three major biomolecules show a general decline, the significance of which is discussed.