Evaluation of Ovulation Effect of Pippalyadi Yoga in Letrozole induced PCOS

Infertility is typically defined as inability or failure to conceive after one year period of continuous exposure to normal unprotected coitus. Mainly the causes in females are an ovulation blocked fallopian tube, hormonal imbalance. Common in males are low sperm count, abnormal sperm morphology. In this regard we took Pippalyadi yoga is herbal formulation mentioned in "Chakradatta" indicated in Vandhya (disorders of female Infertility). Pippalyadi Yoga is one of the Churna Kalpana (Powder dosage form), which contains Pippali, Adraka, Krishna maricha and Nagakeshara. Hence this formulation is expected to contribute positive and better result PCOS.

In the present study letrozole induced PCOS method was followed. Female albino rats, letrozole (to induce PCOS) clomiphene citrate (standard drug) Pippalyadi yoga (test drug) were served as materials for the study. After inducing PCOS and after treatment of PCOS condition rats were sacrificed and Hormonal assay, histomorphometric changes were observed and recorded. The testosterone level decreased after treatment from 1.065 ±1.464 pg/ml to 0.155 ± 0.172 in group 1 (standard drug Clomiphene citrate) and the testosterone level decreased from 0.662 ± 0.5369 Ng/ml to 0.237 ± 0.0568 in group 2 (test drug Pippalyadi yoga).

The test drug Pippalyadi yoga has shown a significant result and like that of standard drug Clomiphene citrate result in letrozole-induced PCOS.