The Biology of Vasopressin

Sparapani, Samantha and Millet-Boureima, Cassandra and Oliver, Joshua and Mu, Kathy and Hadavi, Pegah and Kalostian, Tamar and Ali, Nazifa and Avelar, Carla Maria and Bardies, Marion and Barrow, Brenton and Benedikt, Minky and Biancardi, Giuliana and Bindra, Raminder and Bui, Lisa and Chihab, Zakaria and Cossitt, Ashley and Costa, Jeffrey and Daigneault, Tina and Dault, Jocelyn and Davidson, Isa and Dias, Jonathan and Dufour, Emie and El-Khoury, Sabine and Farhangdoost, Nargess and Forget, Anika and Fox, Alexa and Gebrael, Myriam and Gentile, Maria Concetta and Geraci, Olivia and Gnanapragasam, Ansley and Gomah, Elias and Haber, Elie and Hamel, Claudia and Iyanker, Thivya and Kalantzis, Christina and Kamali, Sara and Kassardjian, Elsa and Kontos, Hryssi Krissy and Le, Thi Bich Uyen and LoScerbo, Daniella and Low, Yan Fang and Mac Rae, Danielle and Maurer, Flore and Mazhar, Sana and Nguyen, Alice and Nguyen-Duong, Kathy and Osborne-Laroche, Chelsea and Park, Hwi Wun and Parolin, Emilie and Paul-Cole, Kahlila and Peer, Leah Sarah and Philippon, Margaux and Plaisir, Charles-Alexandre and Porras Marroquin, Jessica and Prasad, Simran and Ramsarun, Rewaparsad and Razzaq, Saad and Rhainds, Samantha and Robin, Damien and Scartozzi, Ryan and Singh, Davindra and Fard, Sajad Soleimani and Soroko, Maxim and Soroori Motlagh, Nastaran and Stern, Kiri and Toro, Laila and Toure, M. Wyatt and Tran-Huynh, Stephanie and Trépanier-Chicoine, Sarah and Waddingham, Claudia and Weekes, Aaliyah Jasmine and Wisniewski, Allison and Gamberi, Chiara (2021) The Biology of Vasopressin. Biomedicines, 9 (1). p. 89. ISSN 2227-9059

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Abstract

Vasopressins are evolutionarily conserved peptide hormones. Mammalian vasopressin functions systemically as an antidiuretic and regulator of blood and cardiac flow essential for adapting to terrestrial environments. Moreover, vasopressin acts centrally as a neurohormone involved in social and parental behavior and stress response. Vasopressin synthesis in several cell types, storage in intracellular vesicles, and release in response to physiological stimuli are highly regulated and mediated by three distinct G protein coupled receptors. Other receptors may bind or cross-bind vasopressin. Vasopressin is regulated spatially and temporally through transcriptional and post-transcriptional mechanisms, sex, tissue, and cell-specific receptor expression. Anomalies of vasopressin signaling have been observed in polycystic kidney disease, chronic heart failure, and neuropsychiatric conditions. Growing knowledge of the central biological roles of vasopressin has enabled pharmacological advances to treat these conditions by targeting defective systemic or central pathways utilizing specific agonists and antagonists.

Item Type: Article
Uncontrolled Keywords: vasopressin; renal function; cardiac function; social behavior; sex differences; GPCRs
Subjects: STM Repository > Biological Science
Depositing User: Managing Editor
Date Deposited: 06 Mar 2023 06:26
Last Modified: 13 Mar 2024 04:25
URI: http://classical.goforpromo.com/id/eprint/998

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